“After “Married...with Children,” Christina starred in “Jesse,” playing a single mother raising a young son in Buffalo, a waitress working in her father's bar. Christina won a People's Choice Award and was nominated for a Golden Globe fo Lead Actress in a Comedy. The show had outstanding ratings – No. 4 in 1999, No. 12 in 2000 – but was inexplicably canceled.
Christina appeared in two episodes of “Friends” as Amy Green, Rachel's younger sister, earning her an Emmy in 2004 for Outstanding Guest Actress in a Comedy Series.
Christina's most memorable film role was as Will Ferrell's love interest in 2004's “Anchorman: The Legend of Ron Burgundy,” a parody of local TV news and the 1970s lifestyle. Christina, as Veronica Corningstone, disrupted the previously all-male “news team” with her unbridled ambition.
Christina returned to TV in 2007 in “Samantha Who?” the highest-rated sitcom for the first six episodes of the season.
She was diagnosed with breast cancer in 2008 and she was pronounced
cancer free after a double mastectomy. She returned to work on
“Samantha Who?” but the show was canceled the following season after
Six years after it left the air, the “Married...with Children” reunited. Christina recalled the experience in an interview with www.filmmonthly.com
"It was really nice to see everybody. I mean those people raised me and it
was just it was nice to give our audience you know the people their still
our audience,” she said.
“I think that's the thing this question comes up as much as it does is that
here's a show that's still on four times a day and known internationally
whatever, but here when you turn on the television it's on every single day
four times a day. And so you're constantly reminded and those of you who
may not of seen anything else that I've ever done that's all you know. So,
that's cool and I can't, you know, fight that."